I can only really speak of Asperger Syndrome, and within that, myself. It is not uncommon for Aspergians to feel something akin to paranoia. Why akin to? If a person has made more than a couple of social faux pas, they may be justified in believing that they are being watched or spoken about. So, not exactly the irrational belief that they are being observed or are the centre of secret discussions. But a large portion of that feeling is added by the person themselves: I'm not being included, it must be about me. And this is how people with low self confidence, introverts, and some people with AS suffer from an excessive ego.
But being so self-centric can be detrimental to social relationships. No one likes the guy who's a bit of an arse, but it's accidental offenses, rather than the self-interested egotism, that most of us are worried about. The 'oops, they didn't take that right' moments. The 'oh, that's why they're acting funny' moments. You can't change human nature, but you can change your own behaviour. If it upsets you that you've upset someone, you can learn from that. All you can do is learn.
But is this behaviour inherent, or is it learned as self defence? Assume the worst, and everything's an improvement. Not really the best philosophy for life, but getting over the emotional hump, the Wednesday of you ego, is the trick. By no means am I saying change yourself to make people like you, but I am saying try to curb the behaviour that you've found has upset people, because in the end, it's upsetting you. Be selfish in that respect. So, at the risk of sounding pseudo-philosophical, think of yourself and think of others.